Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD(+)) and adenosine triphosphate (ATP) contributes to significant cy...

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Autors principals: Aneja, Rajesh K, Sjodin, Hanna, Gefter, Julia V, Zingarelli, Basilia, Delude, Russell L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051880/
https://ncbi.nlm.nih.gov/pubmed/21345219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-8-3
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