Origins of netropsin binding affinity and specificity: correlations of thermodynamic and structural data.
We report complete thermodynamic profiles for netropsin binding to an oligomeric and to several polymeric DNA host duplexes. These data allow us to reach the following conclusions: netropsin binding by deep penetration into the minor groove is overwhelmingly enthalpy driven and exhibits a very high...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1987
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305088/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3037518/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.13.4359 |
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