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A simple work flow for biologically inspired model reduction - application to early JAK-STAT signaling

BACKGROUND: Modeling of biological pathways is a key issue in systems biology. When constructing a model, it is tempting to incorporate all known interactions of pathway species, which results in models with a large number of unknown parameters. Fortunately, unknown parameters need not necessarily b...

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Detalhes bibliográficos
Main Authors: Quaiser, Tom, Dittrich, Anna, Schaper, Fred, Mönnigmann, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050741/
https://ncbi.nlm.nih.gov/pubmed/21338487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-30
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