Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines

BACKGROUND: Paclitaxel is a microtubule-stabilizing drug that has been commonly used in treating cancer. Due to genetic heterogeneity within patient populations, therapeutic response rates often vary. Here we used the NCI60 panel to identify SNPs associated with paclitaxel sensitivity. Using the pan...

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Main Authors: Eng, Lawson, Ibrahim-zada, Irada, Jarjanazi, Hamdi, Savas, Sevtap, Meschian, Mehran, Pritchard, Kathleen I, Ozcelik, Hilmi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050680/
https://ncbi.nlm.nih.gov/pubmed/21314952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-4-18
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