Bioinformatic analyses identifies novel protein-coding pharmacogenomic markers associated with paclitaxel sensitivity in NCI60 cancer cell lines

BACKGROUND: Paclitaxel is a microtubule-stabilizing drug that has been commonly used in treating cancer. Due to genetic heterogeneity within patient populations, therapeutic response rates often vary. Here we used the NCI60 panel to identify SNPs associated with paclitaxel sensitivity. Using the pan...

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Hoofdauteurs: Eng, Lawson, Ibrahim-zada, Irada, Jarjanazi, Hamdi, Savas, Sevtap, Meschian, Mehran, Pritchard, Kathleen I, Ozcelik, Hilmi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2011
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050680/
https://ncbi.nlm.nih.gov/pubmed/21314952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-4-18
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