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Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells.

The capacity of blood (trypomastigote) forms of Trypanosoma cruzi to infect mouse peritoneal macrophages or rat heart myoblasts in vitro was inhibited by treatment of the trypomastigotes with DL-alpha-difluoromethylarginine (F2Me Arg), monofluoromethylagmatine, or (E)-alpha-monofluoromethyl-3-4-dehy...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kierszenbaum, F, Wirth, J J, McCann, P P, Sjoerdsma, A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305068/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3295879/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4278
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