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The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.
Tumor necrosis factor (TNF) is a macrophage product under active study as an anticancer drug. However, this agent can be very toxic and has been implicated in the pathogenesis of endotoxic shock. After intravenous injection of human recombinant TNF (4 micrograms/g), growing rats showed an unusual co...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1987
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3108890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4273 |
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