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The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.
Tumor necrosis factor (TNF) is a macrophage product under active study as an anticancer drug. However, this agent can be very toxic and has been implicated in the pathogenesis of endotoxic shock. After intravenous injection of human recombinant TNF (4 micrograms/g), growing rats showed an unusual co...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1987
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3108890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4273 |
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