Colchicine prevents tumor necrosis factor-induced toxicity in vivo.

Tumor necrosis factor (TNF) toxicity was induced in vivo by intravenous administration of 15 micrograms of recombinant murine TNF-alpha per kg to galactosamine-sensitized mice. Within 8 h, the animals developed a fulminant hepatitis. Intravenous administration of 0.5 mg of colchicine per kg at 19 an...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Tiegs, G, Freudenberg, M A, Galanos, C, Wendel, A
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257098/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1563785/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.5.1941-1945.1992
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