(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a Matrix Metalloprotease Inhibitor, Is a Novel and Potent Activator of Hypoxia-Inducible Factors

Hypoxia-inducible factors (HIFs) are unstable heterodimeric transcription factors and decisive elements for the transcriptional regulation of genes important in the adaptation to low-oxygen conditions. Hypoxia is the ubiquitous inducer of HIFs, stabilizing the α-subunit and permitting the formation...

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Bibliographic Details
Main Authors: Lauzier, Marie-Claude, Robitaille, Geneviève A., Chan, Denise A., Giaccia, Amato J., Richard, Darren E.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050611/
https://ncbi.nlm.nih.gov/pubmed/18424552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.045690
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