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Altered Renal FGF23-Mediated Activity Involving MAPK and Wnt: Effects of the Hyp Mutation
Fibroblast growth factor-23 (FGF23), a hormone central to renal phosphate handling, is elevated in multiple hypophosphatemic disorders. Initial FGF23-dependent Erk1/2 activity in the kidney localizes to the distal convoluted tubule (DCT) with the co-receptor α-Klotho (KL), distinct from Npt2a in pro...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050595/ https://ncbi.nlm.nih.gov/pubmed/20675303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-10-0181 |
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