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A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53
Cancer cells neutralize p53 by deletion, mutation, proteasomal degradation, or sequestration to achieve a pathologic survival advantage. Targeting the E3 ubiquitin ligase HDM2 can lead to a therapeutic surge in p53 levels. However, the efficacy of HDM2 inhibition can be compromised by overexpression...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050021/ https://ncbi.nlm.nih.gov/pubmed/21075307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.024 |
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