A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

Cancer cells neutralize p53 by deletion, mutation, proteasomal degradation, or sequestration to achieve a pathologic survival advantage. Targeting the E3 ubiquitin ligase HDM2 can lead to a therapeutic surge in p53 levels. However, the efficacy of HDM2 inhibition can be compromised by overexpression...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bernal, Federico, Wade, Mark, Godes, Marina, Davis, Tina N., Whitehead, David G., Kung, Andrew L., Wahl, Geoffrey M., Walensky, Loren D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050021/
https://ncbi.nlm.nih.gov/pubmed/21075307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.024
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