Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo

OBJECTIVE: Skeletal muscle AMP-activated protein kinase (AMPK)α2 activity is impaired in obese, insulin resistant individuals during exercise. We determined whether this defect contributes to the metabolic dysregulation and reduced exercise capacity observed in the obese state. DESIGN: C57BL/6J wild...

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Bibliographic Details
Main Authors: Lee-Young, Robert S., Ayala, Julio E., Fueger, Patrick T., Mayes, Wesley H., Kang, Li, Wasserman, David H.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049903/
https://ncbi.nlm.nih.gov/pubmed/21079619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2010.220
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