IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling

BACKGROUND: In atopic individuals, food ingestion drives the production of IgE antibodies that can trigger hypersensitivity reactions. The IL-4 pathway plays critical roles in this response and genetic polymorphisms in its components have been linked to allergy. OBJECTIVE: To test whether an activat...

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Main Authors: Mathias, Clinton B., Hobson, Suejy A., Garcia-Lloret, Maria, Lawson, Greg, Poddighe, Dimitri, Freyschmidt, Eva-Jasmin, Xing, Wei, Gurish, Michael F., Chatila, Talal A., Oettgen, Hans C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049834/
https://ncbi.nlm.nih.gov/pubmed/21167580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.11.009
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