Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation

During bile duct ligation (BDL), the growth of large cholangiocytes is regulated by the cAMP/ERK1/2 pathway and is closely associated with increased secretin receptor (SR) expression. Although it has been suggested that the SR modulates cholangiocyte growth, direct evidence for secretin-dependent pr...

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Autori principali: Glaser, Shannon, Lam, Ian P, Franchitto, Antonio, Gaudio, Eugenio, Onori, Paolo, Chow, Billy K, Wise, Candace, Kopriva, Shelley, Venter, Julie, White, Mellanie, Ueno, Yoshiyuki, Dostal, David, Carpino, Guido, Mancinelli, Romina, Chiasson, Valorie, DeMorrow, Sharon, Francis, Heather, Alpini, Gianfranco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049759/
https://ncbi.nlm.nih.gov/pubmed/20578263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23657
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