After Damage of Large Bile Ducts by Gamma-Aminobutyric Acid, Small Ducts Replenish the Biliary Tree by Amplification of Calcium-Dependent Signaling and de Novo Acquisition of Large Cholangiocyte Phenotypes

Large cholangiocytes secrete bicarbonate in response to secretin and proliferate after bile duct ligation by activation of cyclic adenosine 3′, 5′-monophosphate signaling. The Ca(2+)-dependent adenylyl cyclase 8 (AC8, expressed by large cholangiocytes) regulates secretin-induced choleresis. Ca(2+)-d...

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Autori principali: Mancinelli, Romina, Franchitto, Antonio, Gaudio, Eugenio, Onori, Paolo, Glaser, Shannon, Francis, Heather, Venter, Julie, DeMorrow, Sharon, Carpino, Guido, Kopriva, Shelley, White, Mellanie, Fava, Giammarco, Alvaro, Domenico, Alpini, Gianfranco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843470/
https://ncbi.nlm.nih.gov/pubmed/20185575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090677
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