After Damage of Large Bile Ducts by Gamma-Aminobutyric Acid, Small Ducts Replenish the Biliary Tree by Amplification of Calcium-Dependent Signaling and de Novo Acquisition of Large Cholangiocyte Phenotypes

Large cholangiocytes secrete bicarbonate in response to secretin and proliferate after bile duct ligation by activation of cyclic adenosine 3′, 5′-monophosphate signaling. The Ca(2+)-dependent adenylyl cyclase 8 (AC8, expressed by large cholangiocytes) regulates secretin-induced choleresis. Ca(2+)-d...

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Detalhes bibliográficos
Main Authors: Mancinelli, Romina, Franchitto, Antonio, Gaudio, Eugenio, Onori, Paolo, Glaser, Shannon, Francis, Heather, Venter, Julie, DeMorrow, Sharon, Carpino, Guido, Kopriva, Shelley, White, Mellanie, Fava, Giammarco, Alvaro, Domenico, Alpini, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843470/
https://ncbi.nlm.nih.gov/pubmed/20185575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090677
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