Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1

Solid tumors contain hypoxic regions in which cancer cells are often resistant to chemotherapy-induced apoptotic cell death. Therapeutic strategies that specifically target hypoxic cells and promote apoptosis are particularly appealing, as few normal tissues experience hypoxia. We have found that th...

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Bibliographic Details
Main Authors: Harrison, Luke R.E., Micha, Dimitra, Brandenburg, Martin, Simpson, Kathryn L., Morrow, Christopher J., Denneny, Olive, Hodgkinson, Cassandra, Yunus, Zaira, Dempsey, Clare, Roberts, Darren, Blackhall, Fiona, Makin, Guy, Dive, Caroline
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049397/
https://ncbi.nlm.nih.gov/pubmed/21393866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43505
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