IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B

HBV is a noncytopathic hepadnavirus and major human pathogen that causes immune-mediated acute and chronic hepatitis. The immune response to HBV antigens is age dependent: viral clearance occurs in most adults, while neonates and children usually develop chronic infection and liver disease. Here, we...

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Main Authors: Publicover, Jean, Goodsell, Amanda, Nishimura, Stephen, Vilarinho, Silvia, Wang, Zhi-en, Avanesyan, Lia, Spolski, Rosanne, Leonard, Warren J., Cooper, Stewart, Baron, Jody L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049376/
https://ncbi.nlm.nih.gov/pubmed/21393863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44198
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