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Synthetic circuit identifies subpopulations with sustained memory of DNA damage

Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopu...

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Bibliografiske detaljer
Main Authors: Burrill, Devin R., Silver, Pamela A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049284/
https://ncbi.nlm.nih.gov/pubmed/21363961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1994911
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