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Synthetic circuit identifies subpopulations with sustained memory of DNA damage
Differential responses to stimuli can affect how cells succumb to disease. In yeast, DNA damage can create heterogeneous responses. To delineate how a response contributes to a cell's future behavior, we constructed a transcription-based memory circuit that detects DNA repair to isolate subpopu...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049284/ https://ncbi.nlm.nih.gov/pubmed/21363961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1994911 |
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