Mutual information identifies sequence positions conserved within the nuclear receptor superfamily: approach reveals functionally important regions for DNA binding specificity

Members of the nuclear receptor superfamily differentiate in terms of specificity for DNA recognition and binding, oligomeric state, and ligand binding. The wide range of specificities are impressive given the high degree of sequence conservation in the DNA binding domain (DBD) and moderate sequence...

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Bibliografiske detaljer
Main Authors: Willis, Scooter, Griffin, Patrick R.
Format: Artigo
Sprog:Inglês
Udgivet: The Nuclear Receptor Signaling Atlas 2011
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Methods
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049237/
https://ncbi.nlm.nih.gov/pubmed/21383938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1621/nrs.09001
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