TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes

TSA-seq mapping suggests that gene distance to nuclear speckles is more deterministic and predictive of gene expression levels than gene radial positioning. Gene expression correlates inversely with distance to nuclear speckles, with chromosome regions of unusually high expression located at the ape...

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Bibliographic Details
Published in:Genome Res
Main Authors: Zhang, Liguo, Zhang, Yang, Chen, Yu, Gholamalamdari, Omid, Wang, Yuchuan, Ma, Jian, Belmont, Andrew S.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2021
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Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849416/
https://ncbi.nlm.nih.gov/pubmed/33355299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.266239.120
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