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miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors
MicroRNAs (miRNAs) were shown to be important for pancreas development, yet their roles in differentiated β-cells remain unclear. Here, we show that miRNA inactivation in β-cells of adult mice results in a striking diabetic phenotype. While islet architecture is intact and differentiation markers ar...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049206/ https://ncbi.nlm.nih.gov/pubmed/21285947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.361 |
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