miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

MicroRNAs (miRNAs) were shown to be important for pancreas development, yet their roles in differentiated β-cells remain unclear. Here, we show that miRNA inactivation in β-cells of adult mice results in a striking diabetic phenotype. While islet architecture is intact and differentiation markers ar...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Melkman-Zehavi, Tal, Oren, Roni, Kredo-Russo, Sharon, Shapira, Tirosh, Mandelbaum, Amitai D, Rivkin, Natalia, Nir, Tomer, Lennox, Kim A, Behlke, Mark A, Dor, Yuval, Hornstein, Eran
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049206/
https://ncbi.nlm.nih.gov/pubmed/21285947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.361
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados