Cooperative Epigenetic Modulation by Cancer Amplicon Genes

Chromosome band 9p24 is frequently amplified in primary mediastinal B-cell lymphoma (PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened an RNA interference library targeting amplicon genes and thereby identified JAK2 and the histone demethylase JMJD2C as essential g...

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Hauptverfasser: Rui, Lixin, Tolga Emre, N. C., Kruhlak, Michael J., Chung, Hye-Jung, Steidl, Christian, Slack, Graham, Wright, George W., Lenz, Georg, Ngo, Vu N., Shaffer, Arthur L., Xu, Weihong, Zhao, Hong, Yang, Yandan, Lamy, Laurence, Davis, R. Eric, Xiao, Wenming, Powell, John, Maloney, David, Thomas, Craig J., Möller, Peter, Rosenwald, Andreas, Ott, German, Muller-Hermelink, Hans Konrad, Savage, Kerry, Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Weisenburger, Dennis D., Chan, Wing C., Gascoyne, Randy D., Levens, David, Staudt, Louis M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049192/
https://ncbi.nlm.nih.gov/pubmed/21156283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.11.013
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