IL-1β Stimulates COX-2 Dependent PGE(2) Synthesis and CGRP Release in Rat Trigeminal Ganglia Cells

OBJECTIVE: Pro-inflammatory cytokines like Interleukin-1 beta (IL-1β) have been implicated in the pathophysiology of migraine and inflammatory pain. The trigeminal ganglion and calcitonin gene-related peptide (CGRP) are crucial components in the pathophysiology of primary headaches. 5-HT1B/D recepto...

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Autors principals: Neeb, Lars, Hellen, Peter, Boehnke, Carsten, Hoffmann, Jan, Schuh-Hofer, Sigrid, Dirnagl, Ulrich, Reuter, Uwe
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048859/
https://ncbi.nlm.nih.gov/pubmed/21394197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017360
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