Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks. Here we investigate the efficacy of two TRPV1 channel antagonists in blocking trigeminal activation using two in vivo mod...

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Dettagli Bibliografici
Pubblicato in:J Headache Pain
Autori principali: Meents, Jannis E, Hoffmann, Jan, Chaplan, Sandra R, Neeb, Lars, Schuh-Hofer, Sigrid, Wickenden, Alan, Reuter, Uwe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Milan 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491068/
https://ncbi.nlm.nih.gov/pubmed/26109436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-015-0539-z
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