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Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks. Here we investigate the efficacy of two TRPV1 channel antagonists in blocking trigeminal activation using two in vivo mod...

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Detalhes bibliográficos
Publicado no:J Headache Pain
Main Authors: Meents, Jannis E, Hoffmann, Jan, Chaplan, Sandra R, Neeb, Lars, Schuh-Hofer, Sigrid, Wickenden, Alan, Reuter, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Milan 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491068/
https://ncbi.nlm.nih.gov/pubmed/26109436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-015-0539-z
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