Mutation of the 5′-Untranslated Region Stem-Loop Structure Inhibits α1(I) Collagen Expression in Vivo

Type I collagen is a heterotrimeric extracellular matrix protein consisting of two α1(I) chains and one α2(I) chain. During liver fibrosis, activated hepatic stellate cells (HSCs) are the major source of the type I collagen that accumulates in the damaged tissue. Expression of α1(I) and α2(I) collag...

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Bibliographische Detailangaben
Hauptverfasser: Parsons, Christopher J., Stefanovic, Branko, Seki, Ekihiro, Aoyama, Tomonori, Latour, Anne M., Marzluff, William F., Rippe, Richard A., Brenner, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048743/
https://ncbi.nlm.nih.gov/pubmed/21193410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189118
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