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Characterization of binding of LARP6 to the 5’ stem-loop of collagen mRNAs: Implications for synthesis of type I collagen

Type I collagen is composed of 2 polypeptides, α1(I) and α2(I), which fold into triple helix. Collagen α1(I) and α2(I) mRNAs have a conserved stem-loop structure in their 5’ UTRs, the 5’SL. LARP6 binds the 5’SL to regulate type I collagen expression. We show that 5 nucleotides within the single stra...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Stefanovic, Lela, Longo, Liam, Zhang, Yujie, Stefanovic, Branko
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615758/
https://ncbi.nlm.nih.gov/pubmed/25692237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2014.996467
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