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Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism

Absent, small, or homeotic disc1 (Ash1) is a trithorax group histone methyltransferase that is involved in gene activation. Although there are many known histone methyltransferases, their regulatory mechanisms are poorly understood. Here, we present the crystal structure of the human ASH1L catalytic...

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מידע ביבליוגרפי
Main Authors: An, Sojin, Yeo, Kwon Joo, Jeon, Young Ho, Song, Ji-Joon
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048721/
https://ncbi.nlm.nih.gov/pubmed/21239497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.203380
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