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Viral Double-stranded RNAs from Vaccinia Virus Early or Intermediate Gene Transcripts Possess PKR Activating Function, Resulting in NF-κB Activation, When the K1 Protein Is Absent or Mutated

PKR is a potent antiviral molecule that can terminate infection by inhibiting protein synthesis and stimulating NF-κB activation and apoptosis. Originally, it was thought that only intermediate and late gene transcription produced double-stranded (ds) RNA to activate PKR during vaccinia virus (VACV)...

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Autors principals: Willis, Kristen L., Langland, Jeffrey O., Shisler, Joanna L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048664/
https://ncbi.nlm.nih.gov/pubmed/21183678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194704
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