The role of the local environment of engineered Tyr to Trp substitutions for probing the denaturation mechanism of FIS

Factor for inversion stimulation (FIS), a 98-residue homodimeric protein, does not contain tryptophan (Trp) residues but has four tyrosine (Tyr) residues located at positions 38, 51, 69, and 95. The equilibrium denaturation of a P61A mutant of FIS appears to occur via a three-state (N(2) ⇆ I(2) ⇆ 2U...

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Xehetasun bibliografikoak
Egile Nagusiak: Muñiz, Virginia A, Srinivasan, Saipraveen, Boswell, Sarah A, Meinhold, Derrick W, Childs, Tawanna, Osuna, Robert, Colón, Wilfredo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wiley Subscription Services, Inc., A Wiley Company 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048415/
https://ncbi.nlm.nih.gov/pubmed/21280122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.561
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