Common and Variable Contributions of Fis Residues to High-Affinity Binding at Different DNA Sequences

Fis is a nucleoid-associated protein that interacts with poorly related DNA sequences with a high degree of specificity. A difference of more than 3 orders of magnitude in apparent K(d) values was observed between specific (K(d), ∼1 to 4 nM) and nonspecific (K(d), ∼4 μM) DNA binding. To examine the...

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Main Authors: Feldman-Cohen, Leah S., Shao, Yongping, Meinhold, Derrick, Miller, Charmi, Colón, Wilfredo, Osuna, Robert
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Genetics and Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1428148/
https://ncbi.nlm.nih.gov/pubmed/16513738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.188.6.2081-2095.2006
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