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Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding
The Sec1/munc18 protein family is essential for vesicle fusion in eukaryotic cells via binding to SNARE proteins. Protein kinase C modulates these interactions by phosphorylating munc18a thereby reducing its affinity to one of the central SNARE members, syntaxin-1a. The established hypothesis is tha...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048386/ https://ncbi.nlm.nih.gov/pubmed/21390273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001097 |
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