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Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
Deposition of proteins of aberrant conformation is the hallmark of many neurodegenerative diseases. Misfolding of the normally globular mutant superoxide dismutase-1 (SOD1) is a central, early, but poorly understood event in the pathogenic cascade leading to familial forms of ALS. Here we report tha...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048161/ https://ncbi.nlm.nih.gov/pubmed/21321227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017275108 |
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