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Frustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins
Proteins have often evolved sequences so as to acquire the ability for regulation via allosteric conformational change. Here we investigate how allosteric dynamics is designed through sequences with nonlinear interaction features. First, for 71 allosteric proteins of which two, open and closed, stru...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048140/ https://ncbi.nlm.nih.gov/pubmed/21307307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018983108 |
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