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Frustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins

Proteins have often evolved sequences so as to acquire the ability for regulation via allosteric conformational change. Here we investigate how allosteric dynamics is designed through sequences with nonlinear interaction features. First, for 71 allosteric proteins of which two, open and closed, stru...

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Hlavní autoři: Li, Wenfei, Wolynes, Peter G., Takada, Shoji
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048140/
https://ncbi.nlm.nih.gov/pubmed/21307307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018983108
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