Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells

Papillary thyroid carcinoma (PTC) is the most common endocrine and thyroid malignancy. The urokinase plasminogen activator receptor (uPAR) plays an important role in cancer pathogenesis, including breakdown of the extracellular matrix, invasion and metastasis. Additionally, there is increasing evide...

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Autori principali: Nowicki, Theodore S, Zhao, Hong, Darzynkiewicz, Zbigniew, Moscatello, Augustine, Shin, Edward, Schantz, Stimson, Tiwari, Raj K, Geliebter, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048079/
https://ncbi.nlm.nih.gov/pubmed/21191179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.1.14362
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