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FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest
During cell proliferation, protein degradation is strictly regulated by the cell cycle and involves two complementary ubiquitin ligase complexes, the SCF (Skp, Cullin, F-box) and APC/C (Anaphase Promoting Complex/Cyclosome) ubiquitin ligases. SCF ligases are constitutively active and generally targe...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048047/ https://ncbi.nlm.nih.gov/pubmed/21135578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.22.13743 |
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