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Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4(DCAF1)
The mechanism by which the FERM domain protein Merlin, encoded by the tumor suppressor NF2, restrains cell proliferation is poorly understood. Prior studies have suggested that Merlin exerts its antimitogenic effect by interacting with multiple signaling proteins located at or near the plasma membra...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048042/ https://ncbi.nlm.nih.gov/pubmed/21084862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.22.13838 |
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