ATM and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress

Activation of the transcription factor NF-κB by multiple genotoxic stimuli modulates cancer cell survival. This response is mediated by a conserved pathway involving the nuclear ATM kinase and cytoplasmic IκB kinase (IKK); however the molecular link between them remains incompletely understood. Here...

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Main Authors: Wu, Zhao-Hui, Wong, Ee Tsin, Shi, Yuling, Niu, Jixiao, Chen, Zhijian, Miyamoto, Shigeki, Tergaonkar, Vinay
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048026/
https://ncbi.nlm.nih.gov/pubmed/20932476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.010
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