Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance

OBJECTIVE: Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder of the primary cilium associated with obesity. In BBS mouse models, ciliary dysfunction leads to impaired leptin signaling and hyperleptinemia before obesity onset. To study the pathophysiology of obesity in BBS, we compa...

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Hauptverfasser: Feuillan, Penelope P., Ng, David, Han, Joan C., Sapp, Julie C., Wetsch, Katie, Spaulding, Emma, Zheng, Yuqian C., Caruso, Rafael C., Brooks, Brian P., Johnston, Jennifer J., Yanovski, Jack A., Biesecker, Leslie G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2011
Schlagworte:
JCEM Online: Advances in Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047221/
https://ncbi.nlm.nih.gov/pubmed/21209035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-2290
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