Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance

OBJECTIVE: Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder of the primary cilium associated with obesity. In BBS mouse models, ciliary dysfunction leads to impaired leptin signaling and hyperleptinemia before obesity onset. To study the pathophysiology of obesity in BBS, we compa...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Feuillan, Penelope P., Ng, David, Han, Joan C., Sapp, Julie C., Wetsch, Katie, Spaulding, Emma, Zheng, Yuqian C., Caruso, Rafael C., Brooks, Brian P., Johnston, Jennifer J., Yanovski, Jack A., Biesecker, Leslie G.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2011
Sujets:
JCEM Online: Advances in Genetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047221/
https://ncbi.nlm.nih.gov/pubmed/21209035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-2290
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires