Patients with Bardet-Biedl Syndrome Have Hyperleptinemia Suggestive of Leptin Resistance

OBJECTIVE: Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder of the primary cilium associated with obesity. In BBS mouse models, ciliary dysfunction leads to impaired leptin signaling and hyperleptinemia before obesity onset. To study the pathophysiology of obesity in BBS, we compa...

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Detalhes bibliográficos
Main Authors: Feuillan, Penelope P., Ng, David, Han, Joan C., Sapp, Julie C., Wetsch, Katie, Spaulding, Emma, Zheng, Yuqian C., Caruso, Rafael C., Brooks, Brian P., Johnston, Jennifer J., Yanovski, Jack A., Biesecker, Leslie G.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047221/
https://ncbi.nlm.nih.gov/pubmed/21209035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2010-2290
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