p53 governs telomere regulation feedback too, via TRF2

p53 takes critical part in a number of positive and negative feedback loops to regulate carcinogenesis, aging and other biological processes. Uncapped or dysfunctional telomeres are an endogenous DNA damage that activates ATM kinase (ataxia telangiectasia mutated) and then p53 to induce cellular sen...

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Bibliografski detalji
Glavni autori: Horikawa, Izumi, Fujita, Kaori, Harris, Curtis C.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2011
Teme:
Research Perspective
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047136/
https://ncbi.nlm.nih.gov/pubmed/21266744
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