SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

OBJECTIVE: Inhibition of the Na(+)-glucose cotransporter type 2 (SGLT2) is currently being pursued as an insulin-independent treatment for diabetes; however, the behavioral and metabolic consequences of SGLT2 deletion are unknown. Here, we used a SGLT2 knockout mouse to investigate the effect of inc...

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Detalhes bibliográficos
Main Authors: Jurczak, Michael J., Lee, Hui-Young, Birkenfeld, Andreas L., Jornayvaz, Francois R., Frederick, David W., Pongratz, Rebecca L., Zhao, Xiaoxian, Moeckel, Gilbert W., Samuel, Varman T., Whaley, Jean M., Shulman, Gerald I., Kibbey, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046850/
https://ncbi.nlm.nih.gov/pubmed/21357472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1328
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