Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models

OBJECTIVE: Type 1 diabetes is an incurable chronic autoimmune disease. Although transplantation of pancreatic islets may serve as a surrogate source of insulin, recipients are subjected to a life of immunosuppression. Interleukin (IL)-21 is necessary for type 1 diabetes in NOD mice. We examined the...

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Hlavní autoři: McGuire, Helen M., Walters, Stacey, Vogelzang, Alexis, Lee, Carol M.Y., Webster, Kylie E., Sprent, Jonathan, Christ, Daniel, Grey, Shane, King, Cecile
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Immunology and Transplantation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046847/
https://ncbi.nlm.nih.gov/pubmed/21357471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1157
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