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RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it

In this issue of the JCI, Wu et al. and Marin et al. describe two new mouse models of inherited disorders of the RAS/MAPK signal transduction pathway that display hypertrophic cardiomyopathy (HCM); the model from the former paper was from a gain-of-function Raf1 mutation, and the model from the latt...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Gelb, Bruce D., Tartaglia, Marco
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046639/
https://ncbi.nlm.nih.gov/pubmed/21339640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46399
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