Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study

INTRODUCTION: The human monoclonal antibody adalimumab is known to induce an anti-globulin response in some adalimumab-treated patients. Antibodies against adalimumab (AAA) are associated with non-response to treatment. Immunoglobulins, such as adalimumab, carry allotypes which represent slight diff...

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Main Authors: Bartelds, Geertje M, de Groot, Els, Nurmohamed, Michael T, Hart, Margreet HL, van Eede, Peter H, Wijbrandts, Carla A, Crusius, Jakob BA, Dijkmans, Ben AC, Tak, Paul Peter, Aarden, Lucien, Wolbink, Gerrit J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046534/
https://ncbi.nlm.nih.gov/pubmed/21187010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3208
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