Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study

INTRODUCTION: The human monoclonal antibody adalimumab is known to induce an anti-globulin response in some adalimumab-treated patients. Antibodies against adalimumab (AAA) are associated with non-response to treatment. Immunoglobulins, such as adalimumab, carry allotypes which represent slight diff...

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Main Authors: Bartelds, Geertje M, de Groot, Els, Nurmohamed, Michael T, Hart, Margreet HL, van Eede, Peter H, Wijbrandts, Carla A, Crusius, Jakob BA, Dijkmans, Ben AC, Tak, Paul Peter, Aarden, Lucien, Wolbink, Gerrit J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046534/
https://ncbi.nlm.nih.gov/pubmed/21187010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3208
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